Cancer claims the lives of over 500,000 Americans a year. Unfortunately, the majority of current cancer therapies are only designed to reduce the growth of primary tumors - an approach that does not directly treat tumor spread or metastatic progression. As a result, despite an ever-growing arsenal of cancer therapeutics, the annual mortality rates from cancer have remained virtually unchanged over the past half-century. The lack of effective therapeutics against the progression of the majority of cancers results, in turn, from an inadequate understanding of the biological pathways that drive the growth of metastatic disease.
This year, over 8 million people will die from cancer globally. For most of these individuals, the cause of death will be metastatic colonization of distant organs by cancer cells. We hope to save lives by developing drugs that target both primary tumors and metastasis.- Dr. Masoud Tavazoie (co-founder) -